Cohort information

NETHERLANDS				WP2
Organization		UMCG
Name of cohort		COVID-HOME
Referring partner		UMCG
Cohort Information	Country(-ies), cities, regions or centers involved	UMCG Groningen, Netherlands
	Time of data collection	03/2020	05/2020
	Enrolment	Inactive
	Study setting	Single center
Population	Age	Children,Adolescents,Adults,Elderly
	Type	Prospective
	Total number of patients	190
	Site of enrolment (WP2)	Outpatient
Data collection	Clinical data	True
	Serological data	True
	Genetic data	True
	Sample collection	True
	Sample collected	Whole blood	Yes
		PBMC	No
		Dry-spot blood	No
		Plasma	Yes
		Serum	Yes
		Stool	Yes
		NP swabs	Yes
		Other	None
Description	The COVID-HOME study addresses key questions of relevance to guide patient care and inform public health guidelines for infection prevention and control in the community and household situation in a single study. The main strength of this study is the early, systematic and prospective follow-up of non-hospitalized SARS-CoV-2 patients during the acute disease evolution with a medium to long-term follow-up. The parameters collected in this study, such as viral load, antibody response, cytokine changes and clinical and laboratory parameters of patient evolution will allow the identification of independent factors/parameters determining evolution of disease, insight in other transmission routes than respiratory ones (such as sexual and faecal-oral), and immune response dynamics in non-hospitalized patients.
Publications	- Impact of Omicron Variant Infection on Assessment of Spike-Specific Immune Responses Using the EUROIMMUN Quan-T-Cell SARS-CoV-2 Assay and Roche Elecsys Anti-SARS-CoV-2-S [Pathology and Molecular Diagnostics] - SARS-CoV-2 Reinfections in Health-Care Workers, 1 March 2020–31 January 2023 [Viruses] - SARS-CoV-2 Breakthrough Infections in Health Care Workers: An Italian Retrospective Cohort Study on Characteristics, Clinical Course and Outcomes [Journal of Clinical Medicine]